Bookcover of Enhanced Early Detection of Breast Carcinoma by Fork head Box Protein
Booktitle:

Enhanced Early Detection of Breast Carcinoma by Fork head Box Protein

LAP LAMBERT Academic Publishing (2019-05-14 )

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ISBN-13:

978-620-0-08439-2

ISBN-10:
6200084394
EAN:
9786200084392
Book language:
English
Blurb/Shorttext:
Breast cancer was the most common type of cancer among females worldwide and was the fourth most common cause of cancer-related deaths. Therefore this study designed to evaluate the gene expressions and protein levels of Foxp3, TGF-β and VEGF genes in benign breast lesions and breast carcinoma as useful markers to enhance the early detection of breast cancer by different techniques and conducted on three groups; invasive breast carcinoma group, high risk patients with benign breast lesions and control group. In current study breast cancer patients recorded a highly significant increase in the mean value of serum VEGF, TGF-β and Foxp3 protein level and gene expressions when compared to the high risk and the control groups. Meanwhile, the high risk had intermediate mean value of VEGF, TGF-β and Foxp3 protein levels and gene expressions between breast cancer and healthy control. These results confirmed with three different techniques (ELISA, qRT-PCR and Flow cytometer). Therefore the levels of VEGF, TGF-β and Foxp3 could be used as, quantitative, accurate, and a sensitive biomarkers and robust assay for the early detection of breast cancer especially in high risk patients .
Publishing house:
LAP LAMBERT Academic Publishing
Website:
http://www.lap-publishing.com/
By (author) :
Effat Tharwat Lotfy, Motawa El-Houseini
Number of pages:
100
Published on:
2019-05-14
Stock:
Available
Category:
Genetics
Price:
5134.03 руб
Keywords:
breast cancer, High risk, VEGF, TGF-β, Foxp3, CD4, CD8, CD4CD25, ELISA, qRT-PCR and Flowcytometer

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