Bookcover of Synthesis of indolylquinoline and acridone alkalaids- A green approach
Booktitle:

Synthesis of indolylquinoline and acridone alkalaids- A green approach

Scholars' Press (2019-04-10 )

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ISBN-13:

978-613-8-82911-9

ISBN-10:
6138829115
EAN:
9786138829119
Book language:
English
Blurb/Shorttext:
We have described the total syntheses of quinoline alkaloids, which include indoloquinoline, naphthyridine alkaloids like perlolidine and acridone alkaloids. Synthesis of 1-oxo-1,2,3,4-tetrahydrocarbazole was achieved with good yield using conventional and microwave procedure (unconventional energy). The utility of indole-3-butanoic acid and ethyl 4-(1H-indol-3-yl)butanoate were studied by adopting various catalysts and solvents. As our major synthetic targets were the indoloquinoline alkaloids, we have used Vilsmeier Haack reaction to synthesis and Fischer-indole synthesis to synthesize 3-(2-(1H- indol-3-yl)ethyl)-2- chloroquinoline and 2,4-dihydroxy-3-(indol-2-)-yl-quinoline from ethyl 4-(1H-indol-3-yl)butanoate and 3-acyl-2,4-dihydroxy quinoline respectively. Our investigations on the Vilsmeier Haack reaction (conventional and microwave procedure) of 3-acyl-2,4-dihydroxy quinoline ended up with an intermediate 3-(3-chloroprop-2-ene-1-al)-2,4-dichloroquinoline. The synthetic utility 3-(3-chloroprop-2-ene-1-al)-2,4-dichloroquinoline towards the construction of acridone by using Wittig mechanism with ethyl 2- (triphenylphosphoranylidene was documented.
Publishing house:
Scholars' Press
Website:
https://www.scholars-press.com
By (author) :
A. Nepolraj, P. Pitchai
Number of pages:
144
Published on:
2019-04-10
Stock:
Available
Category:
Organic chemistry
Price:
5974.93 руб
Keywords:
Quinoline, alkalaids, indolylquinoline, greenchemistry

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